Telling two stories, one past and one present, ef ~ a tale of melodies begins when Yuu meets a girl named Yuuko. He was her first love, and first loves never end. The present story follows Kuze and Mizuki. Kuze has a fatal illness and little time left to live. He tries to break all ties with Mizuki, but things become complicated when she confesses her love for him. Listen as the cadences of first love and heart break harmonize and reach the crescendo!